CoreBiome® 101: Patented Tributyrin (Butyrate Triglycerides) for the Gut-Body Axis

In one sentence: CoreBiome® is a patented tributyrin (butyrate triglycerides) ingredient positioned to deliver butyrate to the colon, supporting gut health and lining, regularity and a healthy inflammatory response.
Also known as: CoreBiome® tributyrin, butyrate triglyceride, tributyrate, butyrate (short-chain fatty acid; SCFA), postbiotic butyrate
Key facts: “vegetables in a capsule”; fermentation produces butyrate; gut lining is often described as internal skin; unbranded names matter (tributyrin, butyrate triglycerides, tributyrate)
Best for: capsule-based gut formulas, gut barrier/lining support, regularity and digestive comfort routines, stacking with prebiotics and probiotics

Key Takeaway

CoreBiome® is a branded, patented tributyrin (butyrate triglycerides) that delivers butyrate to the colon, supporting gut lining integrity and gut barrier function. If someone is building a gut routine from the ground up, a gut-foundation approach is often the most practical place to start. That is exactly where butyrate fits.

What to know first

CoreBiome® is a patented form of tributyrin (butyrate triglycerides) designed to deliver a butyrate to the colon. For gut-health-focused routines, it is a strong choice because it supports the foundational gut lining and gut barrier much like a gut-focused diet rich in vegetables. Vegetables → Fermentation → Butyrate.

What is CoreBiome®?

CoreBiome® is Compound Solutions’ patented, clinically studied and branded tributyrin.

• CoreBiome® is tributyrin (butyrate triglycerides)
• Tributyrin is a butyrate triglyceride
• “Tributyrate” is commonly searched
• Butyrate is one of the three short-chain fatty acids (SCFA)

Why would you use CoreBiome® for gut health?

Because butyrate is foundational to human health – not just digestion.

Butyrate is commonly discussed as fuel for colon lining cells. Supporting those cells supports the gut lining, and supporting the gut lining supports gut-barrier function. CoreBiome® is a perfect fit within the best gut formulas for this reason. 

“Vegetables in a capsule”

Vegetables contain fibers and resistant starch. Some of those vegetables and resistant starches are not digested in the upper GI tract. Those undigested fibers reach the colon, where beneficial bacteria ferment it and produce short-chain fatty acids (SCFA), including butyrate.

CoreBiome® supports butyrate through tributyrin. It is not a replacement for vegetables, but it is a practical complement for real-world diets.

Build your gut routine in 3 steps

For a lot of people, the best gut routine is the one they can actually stick with. And while vegetables, fiber and resistant starch are the long-term foundation, jumping from low fiber to high fiber overnight may cause bloat and other uncomfortable GI-related issues. If your gut feels “louder” when you ramp fiber too quickly, you are not alone.

That is why we like the idea of step 1.

Step 1 is about supporting the gut foundation first, then building the rest of the routine on top of it. Here is what that can look like:

• Step 1: Support the foundation (butyrate-focused support)
  Vegetables ferment in the colon to produce butyrate. Butyrate supports the gut lining and gut barrier function, which is why it is such a foundational part of gut health. CoreBiome® supports butyrate through tributyrin
• Step 2: Feed the pathway (build fiber and resistant starch gradually)
  Once your baseline feels more steady, gradually increase fiber and resistant starch so fermentation can happen consistently. Think vegetables, legumes, whole grains and other fiber-rich foods. Slow and steady usually wins here.
• Step 3: Personalize the stack (prebiotics, probiotics, and targeted add-ons)
  After the foundation and the diet are in place, you can layer in additional tools based on your goals, your diet and your lifestyle. Some people add prebiotics to help feed beneficial microbes, probiotics to introduce specific strains, or other gut-supporting ingredients to round out a complete routine.

Dose 

When it comes to butyrate-focused routines, consistency matters more than complexity. That is why CoreBiome® dosing is best kept simple and easy to remember.

A common starting point is 300mg of active tributyrin, taken first thing in the morning. Many people prefer morning use because it becomes part of an automatic routine, like water, coffee, or whatever your morning habit looks like.

A quick note for formulators and brand builders: dosing guidance should always align with the finished product’s serving size, the full formula context and your substantiation. If you are building with CoreBiome® and want help translating the ingredient story into a clean, consumer-friendly supplement facts panel and positioning language, we are happy to help!

FAQs

What is CoreBiome®?
CoreBiome® is a patented tributyrin (butyrate triglycerides) ingredient delivering butyrate to the colon.

Is CoreBiome® the same as tributyrin (butyrate triglycerides)?
CoreBiome® is a branded and patented tributyrin – tributyrin (butyrate triglycerides) is the unbranded chemical name used globally.

Why does CoreBiome® say “vegetables in a capsule”?
Because vegetables ferment in the colon to produce butyrate, and CoreBiome® delivers butyrate.

Is CoreBiome® a probiotic?
No. Probiotics are live microorganisms. CoreBiome® is a postbiotic ingredient because it delivers a key output associated with fermentation: butyrate.

Can CoreBiome® be stacked with probiotics and prebiotics?
Yes. Many formulas pair a butyrate source with prebiotics and probiotics.

What is the recommended CoreBiome® dose?
A common starting point is 300mg of active tributyrin taken first thing in the morning.

Want the “vegetables in a capsule” story in your next product?

CoreBiome® was built for that clean, easy-to-explain gut foundation message. If you want to see how brands are using CoreBiome® in real formulas (and what to pair it with), swing by the CoreBiome® page, or reach out to us at hello@compoundsolutions.com and say hello. We’ll make it easy!