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Compound Solutions Blog

Ingredient news and scientific research for better products and educated consumers.

Gummies macro — applications for rice-sourced, precision-fermented Reb M with a clean, balanced sweetness curve

Going Stevia-Free? Meet Reb M from Rice-Sourced Ingredients

November 24th, 2025

In one sentence: As labels trend stevia-free, brands are choosing precision-fermented Reb M from rice-sourced ingredients, delivering a clean, balanced sweetness curve and consistent quality.Also known as: stevia-free Reb M; rice-sourced Reb M; precision-fermented Reb M; OnoSweet®Key facts: stevia-free – Non-GMO Project Verified (example: OnoSweet®) – zero glycemic response – consistent lot-to-lotUse cases: Marketers – […]

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Rice plant close-up — source of ingredients used to produce stevia-free Reb M via precision fermentation

Reb A vs Reb M – What’s the Difference, and Why it Matters for Taste

November 19th, 2025

In one sentence: Reb A often reads sharper with a lingering finish, while Reb M presents a cleaner, more balanced sweetness curve, especially when produced via precision fermentation using rice-sourced ingredients.Key facts: stevia-free options exist; different steviol glycosides; distinct sensory arcs; source/pathway affect finish; Non-GMO Project Verified example (OnoSweet®)Use cases: proteins; hydration/RTDs; gummies; soft chews; […]

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Precision fermentation – non-GMO microbes convert rice-sourced ingredients into stevia-free Reb M (OnoSweet®). ow rice-sourced ingredients become stevia-free Reb M via precision fermentation – Non-GMO, consistent performance.

Precision Fermentation for Reb M – How Rice-Sourced Ingredients Become Stevia-Free Reb M

November 14th, 2025

In one sentence: Non-GMO, food-grade microbes convert rice-sourced ingredients into Reb M via precision fermentation, enabling stevia-free labeling with a clean, balanced sweetness curve.Also known as: Reb M from rice-sourced ingredients; precision-fermented Reb M; fermentation-derived Reb MKey facts: stevia-free; zero glycemic response; batch-to-batch consistency; scalable supplyUse cases: proteins; hydration/RTDs; gummies; soft chews; functional foods Learn more: […]

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OnoSweet stevia-free rice-sourced Reb M — precision-fermented, Non-GMO Project Verified

OnoSweet® – The Stevia-Free, Rice-Sourced Natural Sweetener

November 12th, 2025

In one sentence: OnoSweet® is stevia-free Reb M produced via fermentation using rice-sourced ingredients; it’s Non-GMO Project Verified and built for a clean, balanced sweetness curve with a smooth finishAlso known as: rice-sourced Reb M; rice-based Reb M; stevia-free Reb MKey facts: stevia-free – Non-GMO Project Verified – zero glycemic response – consistent lot-to-lot – application-readyUse […]

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The Gut Builds Muscle

The Gut Builds Muscle

July 15th, 2025

It’s not all about protein. Protein consumption has been on a tear for a decade, and it continues to grow. Not just whey, but vegan proteins, collagen, and now fermented and “air protein”. But don’t you just want to eat like a normal person? The good news is that building muscle is not all about […]

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CoreBiome butyrate triglycerides

What Is Butyrate? Everything You Need to Know About This Powerful Postbiotic

June 23rd, 2025

Intro: Butyrate is one of the world’s most researched and talked-about compounds in gut health, and for good reason. Butyrate is a short-chain fatty acid (SCFA)  produced in the colon that supports a healthy metabolism, gut, and immune health. But there’s a catch: most butyrate never gets where it’s needed. That’s why we developed CoreBiome®, […]

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TeaCrine From Compound Solutions

What Is TeaCrine®? Benefits, Dosage & How It Works with Caffeine

June 16th, 2025

What Is TeaCrine®? TeaCrine®, a patented form of theacrine, is a nature-identical compound known for delivering clean, long-lasting energy, enhanced mental focus, and improved mood without the crash, jitters or habituation associated with caffeine. TeaCrine® is often used in pre-workouts, brain health, nootropics, energy drinks, and gaming formulas for its synergistic effects with caffeine and […]

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CSI Gives EFFS about your exercise, food, friends and sleep.

EFFS Given: A Lifestyle Worth Giving A Damn About

June 9th, 2025

Before there were supplements, there was nature. Before there were influencers, there were philosophers and physicians—like Hippocrates—reminding us that movement, food, friendship, and rest are the foundation of health. And while modern science has given us powerful tools to support the body, nothing replaces the basics. At Compound Solutions, we work at the cutting edge […]

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Article: Is Sugar the Next Cigarette?

Is Sugar the New Cigarette? Plus: How to Respond to this Market Demand

May 28th, 2024

Coca-Cola wouldn’t market Coke Zero if it weren’t making money from the “zero -sugar” movement. We’re shifting away from sugar like we’ve shifted away from cigarettes. Learn more about sugar’s impact on the market.   Here are some sugar-substitute sweetening ingredients that just don’t make the cut:  Sucralose and Ace-K are synthetic Monk fruit isn’t […]

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The only butyrate that is made by fermentation in the USA

CoreBiome® is Now Fermented and Made in the USA

May 9th, 2024

It has been five years since we introduced CoreBiome®, our patented, bioavailable, postbiotic butyrate, to the market, and it has been the foundational ingredient for innovative gut health products globally. We have proudly partnered with brands like Gundry MD, Ritual, Beekeepers Naturals and more to deliver meaningful results to consumers everywhere. This has all been […]

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Healthy Alternative to Sugar - Sukré

Finding Healthier Alternatives to Sugar

January 4th, 2024

When looking to satisfy a sweet tooth without spiking blood sugar, consider the prebiotic Sukré, which has been shown to provide sweetness without the blood sugar rise or digestive troubles of other sugar substitutes.

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Best Self starts with Caffeine TeaCrine Dyanmine

Your Customer’s Best Self Starts with a Unique, Patented Combination

December 21st, 2023

New research tells a compelling performance story that resonates with go-getters and good-energy seekers everywhere–your customers. The data show that CTD can boost mental stamina, reaction time, focus and precision during intense cognitive challenges – exactly what’s needed to excel in today’s fast-paced, distraction-filled world.

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DDDA Metabolyte™

Introducing Metabolyte™

December 13th, 2023

DDDA (as Metabolyte™) is not a protein, carbohydrate, fat or ketone. It’s a “fifth macronutrient” – a dicarboxylic acid. DDDA contains approximately seven calories per gram, so it’s calorie content fits between a typical carbohydrate (~four calories/gram) and a fat (~nine calories/gram). This means DDDA is relatively energy dense, but without the downsides of higher […]

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DDDA as Metabolyte™

What types of DDDA are there?

July 24th, 2023

Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) comes in powder form as sodium dodecanedioic acid and potassium dodecanedioic acid. They dissolve easily in water for powder and stick pack dosage forms. Sodium and potassium are the two most important electrolytes for several reasons:   Sodium dodecanedioic acid is NOT sodium chloride (salt). Sodium Metabolyte™ is a […]

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How to formulate with DDDA (as Metabolyte™)

How do I formulate with Dodecanedioic Acid (DDDA)?

July 24th, 2023

Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) comes in powder form, so it’s ideal for powder-into-water applications like hydration, pre workouts, and weight management powders. Metabolyte™ comes in two forms: potassium DDDA and sodium DDDA. The recommended dosing is 1.5g to 3g of total material. It’s possible to go higher for more acute benefits, but 1.5g […]

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DDDA Metabolyte™ Weight Management

Does DDDA support metabolism and weight management?

July 24th, 2023

For dodecanedioic acid (DDDA) (as patent-pending Metabolyte™), research in animals and humans have shown improvements in metabolism and weight management. Metabolic Health Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) has been shown in animal models to not just maintain insulin levels in already healthy ranges, but to also sensitize cells to insulin. This is fundamental to […]

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Metabolyte™ for hydration and weight management.

Does DDDA support hydration?

July 24th, 2023

A resounding “YES!” According to Dr. Andrew Huberman, the best nootropic is healthy, adequate sleep. The second best is hydration. Even mild dehydration can limit cognitive function. So, can we just drink water to hydrate and improve cognitive function? Absolutely. This article is about optimizing hydration above water. We can drink a lot of filtered […]

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