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Category: Formulation

Prebiotics probiotics and postbiotics explained with butyrate as a key postbiotic style output

Postbiotics Explained: Prebiotics vs Probiotics vs Postbiotics

February 6th, 2026

In one sentence: Prebiotics feed beneficial microbes, probiotics add live strains, and postbiotics are the beneficial outputs, with butyrate being one of the most valuable postbiotics for foundational gut support. Also known as: postbiotics, postbiotic supplements, prebiotics vs probiotics vs postbiotics, butyrate postbiotic, postbiotic butyrate, prebiotics, probiotics, postbiotics Key facts: fiber and resistant starch can […]

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CoreBiome® powder featuring tributyrin (butyrate triglycerides) for gut foundation support

CoreBiome® 101: Patented Tributyrin (Butyrate Triglycerides) for the Gut-Body Axis

January 23rd, 2026

In one sentence: CoreBiome® is a patented tributyrin (butyrate triglycerides) ingredient positioned to deliver butyrate to the colon, supporting gut health and lining, regularity and a healthy inflammatory response. Also known as: CoreBiome® tributyrin, butyrate triglyceride, tributyrate, butyrate (short-chain fatty acid; SCFA), postbiotic butyrate Key facts: “vegetables in a capsule”; fermentation produces butyrate; gut lining […]

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egetables and fiber-rich foods that support fermentation and butyrate production in the gut

What Is Tributyrin? Butyrate Triglycerides Explained

January 14th, 2026

In one sentence: Tributyrin (butyrate triglycerides, also called tributyrate) is a triglyceride form of butyrate used in supplements to help deliver butyrate to the colon, where butyrate supports gut lining integrity. Also known as: tributyrin, butyrate triglycerides, tributyrate, butyrate supplement, postbiotic butyrate, CoreBiome® Key facts: vegetables and resistant starch ferment in the colon and produce […]

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Rice panicle macro — rice-sourced ingredients for precision-fermented Reb M (stevia-free)

Not All Reb M Is Created Equal: Why Source Matters (Rice vs Stevia vs Cane/Corn)

December 2nd, 2025

In one sentence: Source shapes finish. Fermented Reb M (e.g., OnoSweet®) from rice delivers a clean, balanced sweetness curve with fewer bitter byproducts than stevia-leaf or cane/corn.Also known as: Reb M; fermented Reb M; stevia-free Reb M; OnoSweet®Key facts: stevia-free; Non-GMO Project Verified (OnoSweet®); zero glycemic response; consistent lot-to-lot; sustainable Use cases: Marketers – “source-matters” story […]

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Gummies macro — applications for rice-sourced, precision-fermented Reb M with a clean, balanced sweetness curve

Going Stevia-Free? Meet Reb M from Rice

November 24th, 2025

In one sentence: As labels trend stevia-free, brands are choosing fermented Reb M from rice, delivering a clean, balanced sweetness curve and consistent quality.Also known as: stevia-free Reb M; rice-sourced Reb M; fermented Reb M; OnoSweet®Key facts: stevia-free – Non-GMO Project Verified (example: OnoSweet®) – zero glycemic response – consistent lot-to-lotUse cases: Marketers – stevia-free […]

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Rice plant close-up — source of ingredients used to produce stevia-free Reb M via precision fermentation

Reb A vs Reb M – What’s the Difference, and Why it Matters for Taste

November 19th, 2025

In one sentence: Reb A often reads sharper with a lingering finish, while Reb M presents a cleaner, more balanced sweetness curve, especially when produced via precision fermentation using rice-sourced ingredients.Key facts: stevia-free options exist; different steviol glycosides; distinct sensory arcs; source/pathway affect finish; Non-GMO Project Verified example (OnoSweet®)Use cases: proteins; hydration/RTDs; gummies; soft chews; […]

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Precision fermentation – non-GMO microbes convert rice-sourced ingredients into stevia-free Reb M (OnoSweet®). ow rice-sourced ingredients become stevia-free Reb M via precision fermentation – Non-GMO, consistent performance.

Fermentation for Reb M – How Rice Becomes Stevia-Free Reb M

November 14th, 2025

In one sentence: Non-GMO, food-grade microbes convert rice-sourced ingredients into Reb M via fermentation, enabling stevia-free labeling with a clean, balanced sweetness curve.Also known as: Reb M from rice-sourced ingredients; fermented Reb M; fermentation-derived Reb M; Reb M from riceKey facts: stevia-free; zero glycemic response; batch-to-batch consistency; scalable supplyUse cases: proteins; hydration/RTDs; gummies; soft chews; […]

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OnoSweet stevia-free rice-sourced Reb M — precision-fermented, Non-GMO Project Verified

OnoSweet® – The Stevia-Free, Rice-Sourced Natural Sweetener

November 12th, 2025

In one sentence: OnoSweet® is stevia-free Reb M produced via fermentation using rice; it’s Non-GMO Project Verified and built for a clean, balanced sweetness curve with a smooth finishAlso known as: rice-sourced Reb M; rice-based Reb M; stevia-free Reb M; Reb M from riceKey facts: stevia-free – Non-GMO Project Verified – zero glycemic response – […]

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Article: Is Sugar the Next Cigarette?

Is Sugar the New Cigarette? Plus: How to Respond to this Market Demand

May 28th, 2024

Coca-Cola wouldn’t market Coke Zero if it weren’t making money from the “zero -sugar” movement. We’re shifting away from sugar like we’ve shifted away from cigarettes. Learn more about sugar’s impact on the market.   Here are some sugar-substitute sweetening ingredients that just don’t make the cut: Sucralose and Ace-K are synthetic Monk fruit isn’t […]

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The only butyrate that is made by fermentation in the USA

CoreBiome® is Now Fermented and Made in the USA

May 9th, 2024

It has been five years since we introduced CoreBiome®, our patented, bioavailable, postbiotic butyrate, to the market, and it has been the foundational ingredient for innovative gut health products globally. We have proudly partnered with brands like Gundry MD, Ritual, Beekeepers Naturals and more to deliver meaningful results to consumers everywhere. This has all been […]

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Best Self starts with Caffeine TeaCrine Dyanmine

Your Customer’s Best Self Starts with a Unique, Patented Combination

December 21st, 2023

New research tells a compelling performance story that resonates with go-getters and good-energy seekers everywhere–your customers. The data show that CTD can boost mental stamina, reaction time, focus and precision during intense cognitive challenges – exactly what’s needed to excel in today’s fast-paced, distraction-filled world.

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DDDA Metabolyte™

Introducing Metabolyte™

December 13th, 2023

DDDA (as Metabolyte™) is not a protein, carbohydrate, fat or ketone. It’s a “fifth macronutrient” – a dicarboxylic acid. DDDA contains approximately seven calories per gram, so it’s calorie content fits between a typical carbohydrate (~four calories/gram) and a fat (~nine calories/gram). This means DDDA is relatively energy dense, but without the downsides of higher […]

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DDDA as Metabolyte™

What types of DDDA are there?

July 24th, 2023

Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) comes in powder form as sodium dodecanedioic acid and potassium dodecanedioic acid. They dissolve easily in water for powder and stick pack dosage forms. Sodium and potassium are the two most important electrolytes for several reasons:   Sodium dodecanedioic acid is NOT sodium chloride (salt). Sodium Metabolyte™ is a […]

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How to formulate with DDDA (as Metabolyte™)

How do I formulate with Dodecanedioic Acid (DDDA)?

July 24th, 2023

Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) comes in powder form, so it’s ideal for powder-into-water applications like hydration, pre workouts, and weight management powders. Metabolyte™ comes in two forms: potassium DDDA and sodium DDDA. The recommended dosing is 1.5g to 3g of total material. It’s possible to go higher for more acute benefits, but 1.5g […]

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DDDA Metabolyte™ Weight Management

Does DDDA support metabolism and weight management?

July 24th, 2023

For dodecanedioic acid (DDDA) (as patent-pending Metabolyte™), research in animals and humans have shown improvements in metabolism and weight management. Metabolic Health Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) has been shown in animal models to not just maintain insulin levels in already healthy ranges, but to also sensitize cells to insulin. This is fundamental to […]

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Metabolyte™ for hydration and weight management.

Does DDDA support hydration?

July 24th, 2023

A resounding “YES!” According to Dr. Andrew Huberman, the best nootropic is healthy, adequate sleep. The second best is hydration. Even mild dehydration can limit cognitive function. So, can we just drink water to hydrate and improve cognitive function? Absolutely. This article is about optimizing hydration above water. We can drink a lot of filtered […]

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DDDA as Metabolyte™

What is DDDA?

July 11th, 2023

When thinking of dodecanedioic acid (DDDA), it’s best to begin with fat. Fats are made up of carbon atoms from 2 – 28 (also known as C2 – C28). Medium chain triglycerides (MCTs) contain glycerol and medium chain fatty acids, typically categorized as C6, C8, C10 and C12. C12 is also known as lauric acid. […]

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best butyrate

Which Form of Butyrate is Best?

May 22nd, 2023

The very best butyrate is bioavailable butyrate from foods rich in fiber. The next best thing is to supplement with superior, patented tributyrin known as CoreBiome®. It’s well known that bioavailable butyrate is the most important nutrient for gut health and overall wellness.   But which butyrate is the best butyrate? In this article, we’ll […]

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Butyrate can help with constipation

Can Butyrate Help with Regularity?

May 22nd, 2023

Butyrate may help alleviate occasional constipation and bloating. This is because butyrate is a short-chain fatty acid that plays a crucial role in gut health and overall wellness. It is produced by our gut bacteria when they ferment dietary fiber in the colon. Butyrate is essential for maintaining the integrity of the gut lining, supporting […]

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