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What does DDDA do? What are the Benefits?

DDDA as Metabolyte™
July 11, 2023

Unlike protein, carbs, fat or even exogenous ketones, Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) helps the body with metabolic flexibility by burning fat for fuel. And unlike glucose, Metabolyte™supports normal insulin sensitivity and blood sugar levels.

Dodecanedioic acid (DDDA) (as Metabolyte™) has been show in animal or human studies to be: 1) an energy fuel 2) an insulin sensitizer 3) a glucose clearer 4) a glycogen sparer 5) and a fatty acid oxidizer. This combination makes Metabolyte™ one of the most unique and healthy compounds discovered for humans. Because insulin sensitivity strikes at the very foundation of health, Metabolyte™ is a pioneer in exercise performance, metabolic health and weight management.

Exercise Performance

Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) is known in animal models to spare glycogen. Studies published in the literature (Mingrone G Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1051-8) show  that people can exercise longer because the muscle will first burn fuel from DDDA (Metabolyte™), then glucose, then glycogen. Other clinical validation studies are ongoing. Mice who ingested Metabolyte™ did run longer when they had some level of metabolic dysfunction (i.e. insulin desensitization and/or abnormal energy production).  This characterizes a majority of Americans. When those same studies were run on metabolically healthy mice, they did not run farther with Metabolyte™. Metabolyte provides energy and salts, such as potassium and sodium, that are lost with perspiration.

Metabolic Health

Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) has been shown in animal models and in humans to not just maintain insulin in already healthy ranges, but to also re-sensitize cells to insulin. This is fundamental to human health, particularly for those who’ve been impacted by the Standard American Diet. The potential implications of better insulin sensitivity in humans include, but aren’t limited to: healthy aging, exercise performance, weight management and overall wellbeing.

Insulin sensitivity starts in the muscle, so Metabolyte’s ability to be rapidly metabolized by muscle is foundational to metabolic health.

Weight Management

Dodecanedioic acid (DDDA) (as patent-pending Metabolyte™) has been shown in animal models to increase metabolic rate (metabolism/calorie burning) and improve fatty acid oxidation (burn fat). When combining a higher metabolic rate and fatty acid oxidation with maintaining insulin levels in already health ranges, it makes for a potentially powerful tool in weight management.

DDDA’s ability to help the body switch from burning carbohydrates to burning fat is what’s known as “metabolic flexibility.” Metabolic flexibility makes DDDA extraordinarily unique because only actual ketosis has been known to do that. Ketones like beta-hydroxybutyrate (BHB) or acetoacetate do not burn fatty acids – only dietary ketosis does. And most people cannot maintain dietary ketosis; so, ingesting DDDA is an ideal next step in weight management after a weight-bearing exercise regimen and good nutrition.


Learn more about DDDA

Connection to DDDA and sports nutrition and hydration research

Let’s look at Weight Management Formulas

What does metabolic health mean? 

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