Dynamine™ is Caffeine’s Best Friend
What is Dynamine™?
In a nutshell, Dynamine™ (methylliberine — 2-methoxy-1,7,9 Tetramethyluric acid) is a faster-acting, harder-hitting form of TeaCrine®.
It’s yet another chemical cousin of caffeine (and theacrine).
Similar to theacrine, methyliberine is found in kucha tea. It’s also naturally occuring in a number of coffee species, including Coffea liberica, Coffea dewevrei and Coffea abeokuta.
Since Dynamine™ is chemically similar to TeaCrine, it’s believed that Dynamine™ (alone or in combination with TeaCrine®) is able to stimulate the central nervous system without impacting your cardiovascular system.
Furthermore, preliminary human studies using Dynamine™ have noted that the onset of action is substantially quicker, with reports of test subjects noting improved energy, mood, and focus (EMF) about 15 minutes post-ingestion with EMF peaking around the 60 minute mark.
In addition to a quicker onset of action, the slight structural differences between Dynamine™ and TeaCrine® also mean that Dynamine™ has a shorter half-life.
Recent Landmark Research: Dynamine™ vs. TeaCrine®!
Building off the previous caffeine + TeaCrine® research noting that caffeine could improve the pharmacokinetics of TeaCrine® in the body, they wanted to test if the same held true of caffeine + Dynamine™.
12 participants took part in the double-blind, 6-arm crossover design with the following supplement protocols:
- Group I: Dynamine™ 25 mg
- Group II: Dynamine™ 100 mg
- Group III: Caffeine 150 mg
- Group IV: Dynamine™ 100 mg + caffeine 150 mg
- Group V: Dynamine™ 100 mg + TeaCrine® 50 mg
- Group VI: Dynamine™ 100 mg + TeaCrine® 50 mg + 150 mg
Subjects reported to the lab between 6:00 and 7:00 am each study day following a 10-hour overnight fast. Individuals also had to abstain from beverages, drugs, or supplements containing alcohol or caffeine for 72 hours and strenuous physical exercise for 24 hours.
Researchers also collected measurements of resting heart rate and blood pressure prior to supplement administration as well as prior to each blood sample taken.
Around 8:00 am on each study day, subjects received their respective treatment for that day.
Blood samples were collected at baseline (pre-dose), and at 15 minutes, 30 minutes, 60 minutes, 90 minutes, and 2, 4, 6, 8, and 24 hours post-ingestion.
As researchers hypothesized, caffeine exposure (area under the curve — AUC) and half-life increased when co-administered with Dynamine™ (Groups IV, V, and VI).
More interesting, is the finding that the combination of caffeine + Dynamine™ + TeaCrine® resulted in the greatest area under the curve!
Specifically, the combination of caffeine + Dynamine™ + TeaCrine® resulted in an exposure THREE TIMES greater than caffeine alone!
Basically, when dosing Dynamine™ and TeaCrine® with caffeine, you can get much longer-lasting energy (3x longer!) than you would using the same amount of caffeine alone. Make sure you check out our Coffee Guide to see other innovative formulas here!
What this means is that you can “get by” using less caffeine overall throughout the day, yet still feel energized, focused, and motivated!
Interested in adding TeaCrine® to your formula? Click here.
Interested in adding Dynamine™ to your formula? Click here.
- Yates, C. R.. “Assessment of Pharmacokinetic Interaction Potential Between Caffeine and Methylliberine [Manuscript in Preparation]”
- He H, Ma D, Crone LB, et al. Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans. J Caffeine Res. 2017;7(3):95-102. doi:10.1089/jcr.2017.0006.
- Wang Y, Yang X, Zheng X, Li J, Ye C, Song X. Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities. Fitoterapia. 2010;81(6):627-631. doi:https://doi.org/10.1016/j.fitote.2010.03.008.
- Kuhman DJ, Joyner KJ, Bloomer RJ. Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women. Nutrients. 2015;7(11):9618-32. Published 2015 Nov 19. doi:10.3390/nu7115484
- Taylor L, Mumford P, Roberts M, et al. Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. J Int Soc Sports Nutr. 2016;13(1):1-14. doi:10.1186/s12970-016-0113-3.
- Taylor L, Mumford P, Roberts M, et al. Safety of TeaCrine®®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. J Int Soc Sports Nutr. 2016;13(1):1-14. doi:10.1186/s12970-016-0113-3.
- Timothy S. Murbach, Róbert Glávits, John R. Endres, et al., “A Toxicological Evaluation of Methylliberine (Dynamine®),” Journal of Toxicology, vol. 2019, Article ID 4981420, 25 pages, 2019. https://doi.org/10.1155/2019/4981420.